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Organoids on Psychedelics

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This article is about the interactive demo. For the search engine that hosts it, see David's Internet.
Organoids on Psychedelics
TypeInteractive demo
OriginVoytek Lab at UC San Diego
DeveloperDavid
Written inMATLAB, Python, FOOOF / specparam, TypeScript
TestsFOOOF port fixture-tested; interactive panels use labeled synthetic data
Built withVoytek Lab analysis code, presented as a five-chapter demo
Hosted onDavid-Internet/demos/organoids
Websitehttps://david-internet.vercel.app/demos/organoids

Organoids on Psychedelics is an interactive demonstration of cortical-organoid electrophysiology analysis conducted in the Voytek Lab at UC San Diego. It is hosted on David's Internet and presents the work in five chronological chapters.[1]

The demo covers local field potential preprocessing, spectral fitting, dose and time comparisons, spike and network-event detection, and an analysis-library dependency map. Its interactive panels use labeled synthetic data, while accompanying figures are rendered analysis outputs.

Overview

The first chapter follows a well's signal from Axion raw data through bandpass filtering, downsampling, and HDF5 export. Later chapters show 5-MeO-DMT on Plate D and psilocybin, LSD, psilocin, and vehicle conditions on Plate F. A 48-well raster displays bursts and network events, with controls for time, stimulation, and dose.

Spectral parameterization

A selected well's power spectrum is decomposed with FOOOF or specparam into an aperiodic component and periodic peaks. FOOOF draws the aperiodic fit then the peaks. The panel can switch between fixed and knee models, while the dose view shows parameter heatmaps across days.

Development

The demo reworks analysis from July 2024 to June 2025 into a browser presentation. It includes a fixture-tested TypeScript port of the FOOOF fitting algorithm and ports of the burst and network-event functions. FOOOF port fixture-tested; interactive panels use labeled synthetic data.

See also

References

  1. ^ content/organoids/README.md, David's Internet.
Categories:
  • Interactive demos
  • Neuroscience
  • 2026 establishments